This study conducts an intersectional analysis of the persistent gender disparities within African diplomatic practices, examining the complex interplay between political structures, economic factors, and cultural norms. Despite continental commitments to gender equality and notable progress in select nations like Rwanda, significant underrepresentation of women persists in foreign services, contradicting development goals and wasting critical human capital. Utilizing a mixed-methods sequential explanatory design, this research employs quantitative surveys and qualitative case studies across six African nations to investigate the root causes of these imbalances. It seeks to answer how cultural values shape inclusivity, what economic factors influence women’s pathways to leadership, and to what extent existing policies effectively address unique challenges. The study hypothesizes that constitutional quotas, economic empowerment, and mentorship significantly impact female representation and career progression. Expected findings will advance feminist international relations theory by centering African perspectives and will provide evidence-based recommendations for policymakers and diplomatic institutions. Ultimately, this research aims to develop a comprehensive framework for promoting sustainable gender inclusivity, thereby enhancing Africa’s ability to leverage its full human potential in an increasingly influential global role.