This study investigates the impact of networking sciences (NS) on different management practices, such as operational effectiveness and efficiency (OEE), business decision-making (BDM), planning and development (PD), and formulation of strategies and tactics (FST). This research followed a mixed-method design, including a quantitative survey and qualitative approaches, applying a systematic literature review. The data findings from the quantitative study evident that networking sciences influence four management processes, including OEE at 44.2%, PD at 52.1%, BDM at 48.6%, and FST at 48.4% variances. All these statistical relationships are significant at 0.01 level. Further, these results are supported by qualitative findings through the exploration of current trends in the adoption of NS, including edge computing, cloud networking, and unified communication. The systematic review of articles emphasized the integration of advanced networking sciences is providing benefits for businesses in terms of competitive advantage, scalability, and agility. On the other hand, qualitative analysis highlights the significant role of NS in improving Cross functional collaboration, enhancing decision-making, enabling data-driven strategies, and fostering real time data access. In conclusion, the networking sciences impact management practices involved in organizations to improve operational efficiency and achieve strategic success.