This study investigated the influence of role conflict and role ambiguity on the job satisfaction of Business Educators in Colleges of Education in North-East Nigeria. The research was motivated by the critical role these educators play in national development and the unique, challenging context of the North-East region, characterized by insecurity, underfunding, and administrative inefficiencies. A descriptive survey design was adopted, and data were collected from a sample of 98 Business Educators across six Colleges of Education using a structured questionnaire. The data were analyzed using mean and standard deviation for the research questions and multiple regression to test the null hypotheses at a 0.05 significance level. The findings revealed that both role conflict ( = 0.612, p = 0.000) and role ambiguity ( = 0.558, p = 0.000) have a statistically significant negative influence on job satisfaction. Role conflict accounted for 37.5% of the variance in job satisfaction, while role ambiguity accounted for 31.1%. The study concludes that incompatible job demands and a lack of role clarity are major determinants of professional dissatisfaction among Business Educators in this region. It is recommended that college management develop clear role descriptions and streamline communication, while policy makers should prioritize targeted funding for practical resources to mitigate these role stressors and improve the quality of vocational teacher education.