The present article deals with the important National Development Strategies in favour of economic growth and development of the three Sahel countries of West Africa which have proven uprightly to handle the challenges of neo-colonialism uprightly strengthen by diverse actors of the 21^st Century. The three countries with leaders as Strongmen of the region from Burkina Faso, Mali and Niger decided to take the neo-colonial agents and institutions in an embarrassing realistic ways to end years of suffering by their populations by ousting out the then complicity leaders to the expiring of their masters thereby marking the u unhidden beginning of conflicting bilateral relations from their looters of natural resources through various mechanisms of exploitations. Their recent reflections to exploit their natural resources for the beneficiary of their citizens facing sporadic poverty since the second half of the 20^th Century seems to be putting more blisters and  terrible wounds to the existing neo-colonial Multinational Corporations in their agenda of continuous exploration and exploitation of lucrative natural resources of those countries where they saw themselves exposed to have been using it to the detriment of the local populations due to high rate of underdevelopment with countries tortured as Heavily Indebted Poor Countries (HIPC) initiatives due to accumulated unplayable debts owing to the aid donors countries who are at the same time principal neo-colonial actors in the countries. While facing counter reactions from their main looters of natural wealth, In fact, local initiatives from the three Sahel States are proving more beneficial to the realities of the local population as compared to the previous years under the elected democratic regimes as opposed the choices of the present military leaders who are having their population at heart thereby weakening the previous slogan of Western  hegemonic ambitions in such unchallenging exclusive sphere of influences of the Post-Colonial era of the 21^st Century. The scrutinized of diverse sources of documentations enable us to use a historical approach which open more avenure to the future researchers of Africa in International Relations and related field of studies during the 21^st Century considering the challenging strategies of globalization.