Introduction: Endoscopic procedures performed to evaluate diseases are the gold standard diagnostic procedures in some cases. During the endoscopic procedure, the patient’s pathology is evaluated with the eye of the endoscopist. Based on this evaluation(visual assessment), the endoscopist decides whether to take a biopsy or not. We evaluated the accuracy of the evaluation of patients who were not biopsied according to this evaluation method, with the pathological examination sent to the second endoscopist and performed together with the endoscopy.

Material–Method: 60 patients diagnosed with malabsorption between 2019-2021 were included in the study. All of the patients were patients whose biopsy was not taken in their first endoscopies because of normal appearance, but malabsorption was detected in their clinical controls

Result: In the first endoscopies of 60 patients included in the study, duodenal biopsy was requested for the etiology of malabsorption, which was tried to be clarified in the patient’s clinic, and biopsy was not taken because there was no pathology observed by the endoscopist. Duodenitis was found in the biopsy of 58 (96.6%) of the patients who were biopsied in another center in the second endoscopies of all patients with the preliminary diagnosis of malabsorption.

Discussion: Failure to take the biopsy requested by the doctor who performs the clinical follow-up may lead to different clinical treatment disruptions, and the evaluation for the patient may be inaccurate and incomplete.