This study investigated the perceived occupational safety practices of healthcare workers in teaching hospitals, Rivers State. A cross sectional research design was adopted with a population consisting of 3,673 healthcare workers in teaching health facilities in Rivers State. The sample size of 792 was selected using simple random sampling technique. Data was collected using structured questionnaire with a reliability coefficient of 0.78 and analysis carried out using mean and One-Way Analysis of variance (ANOVA) at 0.05 alpha level. The result further showed that the extent of occupational safety practice was high (3.43±0.55). Also, statistically significant difference was found between occupational safety practice and variables such as job specification [F(7, 739) = 126.46; p<0.05], and years of work experience [F(2, 746) = 12.79; p<0.05]. Based on the findings of the study, it was concluded that, healthcare workers practiced safety measures to a high extent, but occupational health problems are still high which suggests that the health problems are inherent in the job hence, the healthcare workers must prioritize and intensify safety practice when discharging their duty. The ministry of health should constitute a safety team or committee whose duty will be to constantly organize training for the healthcare worker on work safety and also to visit such facilities for safety inspection from time to time.