The rapid digitisation of health‑care delivery in Nigeria has intensified the need to understand factors that safeguard the digital well‑being of health‑care professionals (HCPs). Drawing on the Job Demands‑Resources (JD‑R) model this study examined the direct effects of job autonomy and core self‑evaluation (CSE) on digital well‑being and the moderating role of CSE in the autonomy–digital well‑being link. Using digital wellbeing scale, work design questionnaire and the core self-evaluations scale, a cross‑sectional survey of 180 Nigerian physicians, nurses, and allied health staff yielded three principal findings: Job autonomy positively predicts digital well‑being; CSE positively predicts digital well‑being and CSE moderates the autonomy–digital well‑being relationship, such that the association is stronger for professionals with higher CSE. These findings highlight the importance of fostering job autonomy while considering personality traits in interventions aimed at improving digital wellbeing in healthcare settings.