The National Education Policy (NEP) 2020 represents a transformative paradigm shift in Indian education, emphasizing holistic development through the integration of Indian Knowledge Systems (IKS) with contemporary multidisciplinary learning approaches. This paper examines the conceptual framework of holistic education as envisioned in NEP 2020, analysing how traditional Indian pedagogical wisdom is being systematically integrated into modern curricula to foster comprehensive student development. The study explores the philosophical underpinnings of IKS, including ancient texts, indigenous practices, and cultural heritage, and their relevance in addressing 21st-century educational challenges. Through critical analysis of NEP 2020 provisions, this paper investigates the implementation strategies for multidisciplinary learning that bridge disciplinary boundaries while preserving the essence of Indian intellectual traditions. The research highlights key challenges in operationalizing holistic education, including curriculum design, teacher preparedness, assessment reforms, and institutional restructuring. Findings suggest that successful integration of IKS requires systemic changes in pedagogical approaches, infrastructure development, and stakeholder engagement. The paper concludes that NEP 2020’s vision of holistic education through IKS integration offers a unique opportunity to create culturally rooted yet globally competitive educational ecosystem that nurtures well-rounded individuals equipped with both traditional wisdom and contemporary competencies.