This paper investigates the phenomenon of youth anxiety in African contexts through an exegetical and therapeutic engagement with Proverbs 12:25. The study aims to bridge biblical wisdom and contemporary therapeutic approaches by integrating exegetical insights, cognitive-behavioral therapy (CBT), symbolic interactionism, African Indigenous healing traditions, and cinematic narratives such as Pixar’s Inside Out 2. Methodologically, the research employs a multidisciplinary design. First, an exegetical analysis of the Hebrew text of Proverbs 12:25 is conducted to uncover its semantic, literary, and theological depth. Second, therapeutic correlations are drawn between the proverb’s emphasis on verbal affirmation and cognitive-behavioral therapy’s principles of cognitive reframing. Third, the study situates these insights within African cultural frameworks, examining communal values, verbal rituals, and symbolic healing practices. Finally, the research uses Inside Out 2 as a case illustration to visualize anxiety’s internal dynamics and its social implications for youth. The findings reveal that Proverbs 12:25 encapsulates the dual reality of anxiety’s psychological burden and the restorative capacity of affirming words, a principle mirrored in both cognitive-behavioral therapy and African oral traditions. Symbolic interactionism further highlights how social communication shapes self-perception, while cinematic representation enhances emotional literacy among young audiences. The paper recommends developing integrative therapeutic models that blend cognitive-behavioral therapy, biblical wisdom, and African healing practices; using media and storytelling to normalize anxiety discourse; training youth workers in emotional and symbolic literacy; fostering peer mentorship networks; and advancing localized research to strengthen culturally grounded interventions.